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Laura Valentina Renna, Francesca Bosè, Sara Iachettini, Barbara Fossati, Lorenzo Saraceno, Valentina Milani, Roberto Colombo, Giovanni Meola, Rosanna Cardani
Receptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle
www.plosone.org
www.plosone.org
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(32)Tj
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(37)Tj
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4.3994 0 Td
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1.4683 0 Td
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1.4683 0 Td
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3.0501 0 Td
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1.0318 0 Td
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Q
q
1 j
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0 w
7.4999 0 0 6.6659 219.2881 191.8488 cm
BT
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1 TL
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ET
Q
q
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BT
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(in)Tj
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ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 364.8755 126.822 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(LR)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 375.7606 122.4 cm
BT
/F9 1 Tf
1 TL
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(mice)Tj
2.1543 0 Td
(AMPK/mTORC1)Tj
7.2963 0 Td
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3.8494 0 Td
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3.2485 0 Td
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2.3584 0 Td
(in)Tj
1.0318 0 Td
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ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 545.7259 113.8393 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(LR)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 556.611 109.4173 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(mice)Tj
-35.6596 -1.3039 Td
(no)Tj
1.2756 0 Td
(changes)Tj
3.4016 0 Td
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1.0374 0 Td
[( !)8(")]TJ
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2.2904 0 Td
(alternative)Tj
4.4164 0 Td
(splicing)Tj
3.3165 0 Td
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2.1203 0 Td
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7.2963 0 Td
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1.0262 0 Td
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1.1508 0 Td
(independent)Tj
5.2724 0 Td
(of)Tj
1.0148 0 Td
(insulin)Tj
2.9877 0 Td
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3.5547 0 Td
(deficiency)Tj
4.2689 0 Td
([)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
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q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 431.7732 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Insulin)Tj
3.0472 0 Td
(resistance)Tj
4.6985 0 Td
(and)Tj
1.8567 0 Td
(myotonic)Tj
4.1599 0 Td
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ET
Q
q
1 j
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36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
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(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
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4.089 0 Td
(87)Tj
0 g
2.0906 0 Td
(September)Tj
5.0386 0 Td
(15,)Tj
1.5874 0 Td
(2017)Tj
32.2798 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(23)Tj
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-66.402 84.0904 Td
(decision)Tj
3.2882 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
0.9992 0 Td
(preparation)Tj
4.4433 0 Td
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0 -2.126 Td
(Competing)Tj
4.3795 0 Td
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